Influence of Cochleostomy and Cochlear Implant Insertion on Drug Gradients following Intratympanic Application in Guinea Pigs
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چکیده
منابع مشابه
Intratympanic and Round-Window Drug Therapy: Effect on Cochlear Tinnitus.
Tinnitus is a common symptom for which few existing therapeutic approaches can produce reliable reduction or elimination. Chemical perfusion involves the delivery of medication directly into the inner ear via the round-window membrane. This report discusses the use of dexamethasone or gentamicin in 20 individuals who had inner ear diseases in which disturbing cochlear tinnitus was one of the sy...
متن کاملEvaluation of Seroconversion in Guinea Pigs Following Inoculation of New Formulations of Rubella Vaccine
Background and Aims: Rubella is a contagious viral disease mostly with mild clinical symptoms and often remains undiagnosed. Rubella infection may adversely affect pregnancy, especially in the first trimester and this mother to child transmission can cause congenital rubella and may be lead to permanent disability and mortality in children. Effective rubella vaccine should be prepared using sui...
متن کاملPerilymph pharmacokinetics of marker applied through a cochlear implant in guinea pigs
Patients undergoing cochlear implantation could benefit from a simultaneous application of drugs into the ear, helping preserve residual low-frequency hearing and afferent nerve fiber populations. One way to apply drugs is to incorporate a cannula into the implant, through which drug solution is driven. For such an approach, perilymph concentrations achieved and the distribution in the ear over...
متن کاملCisplatin effects on guinea pigs: cochlear histology and genotoxicity.
UNLABELLED To understand how the DNA answers to external agents such as cisplatin may be relevant to the diagnosis and treatment of hearing disorders caused by the administration of such drug. OBJECTIVES To investigate the cisplatin influence on the cochlea and DNA of guinea pigs. MATERIAL AND METHODS Experimental study carried out with 12 guinea pigs (Cavia porcellus). The inclusion criter...
متن کاملThe Cochlear Implant
The studies on cochlear implants have been conducted in the United States, Austria, Brasil, France, Finland, and some other countries. Up to now, this technique does not seem to have a wide spread application. Indeed it can only apply cases of deafness still presenting sufficient neural remnants to transmit the message. Moreover, the patient must be totally deaf( quasi complete loss of har cel...
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ژورنال
عنوان ژورنال: Audiology and Neurotology
سال: 2013
ISSN: 1420-3030,1421-9700
DOI: 10.1159/000353534